RAF Typhoon FGR4s have operated alongside French warplanes in a joint strike against an underground arms cache in Syria operated by the IS group, per a report from the British defence ministry.
The facility, located using intelligence, was assessed as containing munitions and bombs, the announcement noted, and was situated in mountainous terrain just to the north of the ancient city of Palmyra in Syria's central region.
"The RAF jets used Paveway IV guided bombs to target a several entry passages leading to the site... early reports are that the strike was effective," officials stated.
There was no evidence of any civilian casualties in the operation late on Saturday and every plane involved made a safe return, the defence officials confirmed.
The British jets were assisted by a Voyager tanker plane.
IS - also known as Daesh - enforced jihadist rule over parts of Syria and Iraq prior to its 2019 collapse.
"This operation shows our UK leadership, and resolve to work closely with allied nations, to eradicate any re-emergence of the terrorist group and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief John Healey remarked.
UK warplanes have conducted overwatch operations over Syrian airspace to "forestall any efforts to regroup" of the group subsequent to its routing at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of our armed forces who took part in this operation for their expertise and their courage," he said. "They were part of a great many British personnel deployed over the festive period. This mission, to eliminate militants who threaten our safety, shows how UK forces are always on standby, throughout the year, keeping Britain secure domestically and strong abroad."
Last December, the United States armed forces executed what it termed a "major assault" targeting Islamic State objectives in Syria, following an attack claimed the lives of two US servicemembers and a civilian linguist in Palmyra.
The United Nations reports Islamic State still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.